Your handler doesn't look correct. you should use DataListCommandEventArgs
as second parameter. so try something like this
Markup:
<asp:DataList ID="DataList1" runat="server" OnItemCommand="DataList1_ItemCommand" vCellPadding="10" DataKeyField="product_id" DataSourceID="SqlDataSource1" RepeatColumns="2">
Then Add command name in button
<asp:Button ID="ButtonAddToCart" runat="server" Text="Add to Cart" CommandName="addtocart2" />
and code behind
public void DataList1_ItemCommand(object source, DataListCommandEventArgs e)
{
if(e.CommandName.Equals("addtocart2")
{
TextBox qtytxtbox = (TextBox)(e.Item.FindControl("Qty"));
}
}