Please, don't even think about doing this on a database level. Seriously. Changes made to the database layer directly will not be visible inside the system and lead to all kinds of strange side effects that will be a nightmare to support. Besides, your changes won't be picked up by the Change and Transport System - you'd have to update the QA and Production systems manually.
If possible, I'd recommend to choose your domain values in a way that the neutral field value (spaces, zero, whatever) corresponds to your default value. If this is not possible, please describe your scenario in detail to get a more specific answer.
The SAP R/3 / ABAP environment does not give you the option of adding default values for a column. You can only choose to force the system to fill the non-NULL
default values when adding a column, but this is usually a bad idea. It takes time to modify all the data and insert the default values, and depending on the table size and criticality, this can lead to a production outage. Filling the fields with default values has to be performed by the application server, not the database. In your case, I'd just add the logic in the read-access module, something like
IF my_user-ze_design IS INITIAL.
my_user-ze_design = co_ze_default_design.
ENDIF.