The mod_python package is no longer developed or supported and has not been updated in many years. If it still works with the latest Python 2.X versions you would be lucky. The mod_python package doesn't use the Python threading APIs properly. In Python 3.X they changed the obligations on how the threading API is used. If any of that got back ported to Python 2.7, then mod_python would likely break because of its incorrect threading API usage.
Short answer is that you don't want to be using mod_python these days.