At present it is impossible to redefine a class at runtime such that the redefinition will result in new methods or fields. This is due to the complexity involved in scanning the heap for all existing instances and transforming them + their references + potential Unsafe field offset base updaters (like AtomicFieldUpdater).
This limitation may be lifted as part of the JEP-159 but as discussed on the concurrency-interest mailing group this is a big impact change so may never happen at all.
Using Javaassist/similar will allow the transformation of a class to a new class with new methods/fields. This class can be loaded by a ClassLoader and used at runtime, but it's definition will not replace existing instances. So it will not be possible to use this method combined with an agent to redefine the class as an instrumentation redefinition is limited such that: "The redefinition may change method bodies, the constant pool and attributes. The redefinition must not add, remove or rename fields ..." see here.
So for now, NO.