See if this is more clear. You don't need the IIF function to check a Yes/No value at the WHERE clauses. Aditionally, parenthesis are required to express the logic: (x OR y OR z) AND w
SELECT null as Status,
sum(IIF(layer='key info',1,0)) AS [Key Info],
sum(IIF(layer='approaches',1,0)) AS [Approaches],
sum(IIF(layer='research',1,0)) AS [Research]
FROM resources
WHERE (literacy OR numeracy OR poverty)
UNION
SELECT [copyright status],
sum(IIF(layer='key info',1,0)) AS [Key Info],
sum(IIF(layer='approaches',1,0)) AS [Approaches],
sum(IIF(layer='research',1,0)) AS [Research]
FROM resources
WHERE (literacy OR numeracy OR poverty)
GROUP BY [copyright status]
UNION
SELECT [lw status],
sum(IIF(layer='key info',1,0)) AS [Key Info],
sum(IIF(layer='approaches',1,0)) AS [Approaches],
sum(IIF(layer='research',1,0)) AS [Research]
FROM resources
WHERE (literacy OR numeracy OR poverty) AND [lw status] = 'In Reserve'
GROUP BY [lw status]
UNION
SELECT [lw status],
sum(IIF(layer='key info',1,0)) AS [Key Info],
sum(IIF(layer='approaches',1,0)) AS [Approaches],
sum(IIF(layer='research',1,0)) AS [Research]
FROM resources
WHERE (literacy OR numeracy OR poverty) AND [lw status] = 'Published'
GROUP BY [lw status];
Regards