I very much doubt it would help in that regard.
While mutli_query is useful, the RDS server is still running the same number of queries,IOPS are counted for any reads or writes to your RDS instance that is related to the database software. That includes logs as well (binlog, but also error log, general log, etc), temporary files, etc.
You will also find that long or complex queries will count as multiple IOPS. Read replicas will also cause additional IOPS since they are reading a binlog and then running queries based on that.
So it is unlikely that putting multiple queries into one call would lower the iops used.