Yes you can do that, this sample uses onmouseover/out
in JS and onClick
in VBScript.
<script type="text/vbscript">
Function MyVbAlert()
MsgBox("Hello from VB Script!")
End Function
</script>
<script type="text/javascript">
function myJsMouseOver(c) {
c.style.color = 'green'
}
function myJsMouseOut(c) {
c.style.color = 'black'
}
</script>
<span onclick="MyVbAlert()" onmouseover="myJsMouseOver(this)" onmouseout="myJsMouseOut(this)" >Click Me</span>