Pick a trace template (such as Tuning) and use a filter.
Either filter by a particular login (such as your own login or a service's login), or a particular database.
For instance, to filter by database: Under Trace properties -> Events tab -> Select show all columns. Set a Like
filter on database name.
I find setting a filter on the number of Logical Reads
of say > 10
reads, filters out most of the noise.