Assuming the page has jQuery loaded, you can click each one with a delay in between:
(function(){
var unfollowButtons = $('button.Unfollow');
var index = unfollowButtons.length-1;
unfollow();
function unfollow(){
if(index >= 0){
$(unfollowButtons[index--]).click();
setTimeout(unfollow, 500);
}
}
})();