An excerpt from one of the best blog series ever written about the Guid:
There are a number of possible strategies for making a unique GUID, and in fact information about the strategy used is encoded in the first four bits of the third "group"; almost every GUID you see will be of the form {xxxxxxxx-xxxx-1xxx-xxxx-xxxxxxxxxxxx} or {xxxxxxxx-xxxx-4xxx-xxxx-xxxxxxxxxxxx}.
If there is a one in that place then the algorithm used to guarantee uniqueness is essentially a variation on the ISBN strategy. The GUID is guaranteed to be unique "in space" by choosing some of the bits as the MAC address of the network card in the machine. (The tricky problem of ensuring that no two network cards in the world have the same MAC address is solved somehow by someone else; how that problem is solved, we don't particularly care. The cost of solving that problem is passed on to you, the consumer, in the purchase cost of the network card.)
In short, it's very unlikely that they would ever collide.