Yes, this is possible, but you won't be able to use some of the features of Agile Toolkit (including CRUD).
Commonly this is used in the Front-end development. For example, you would want to have your own Lister (or CompleteLister) template which will link directly to editing page:
Set js_widget
property of Form to null to disable JS enhancement. This way Agile Form would be submitted normally, no AJAX. You would need to act accordingly inside isSubmitted()
check.
CRUD, Popovers and many other features wouldn't work, but then again other frameworks don't offer them to you anyway.
See also: