The official wrapper around the Twitter API for Python is this one. I used it and it's very easy. You should first read this page and also register an application to get OAuth keys.
Example:
import twitter
# Remember to put these values
api = twitter.Api(consumer_key="",
consumer_secret="",
access_token_key="",
access_token_secret="")
# Get your timeline
print api.GetHomeTimeline()
Hope it helps.