All files flagged as resources: images, not dinamic web pages, CSS, javascripts, *.xsd etc.
All other files used by your enterprise application need a weblogic restart.
For example: you have some *.properties files read during the startup of the server to create a singleton. Those files, read ONLY during the startup, need a full weblogic restart in order to be refreshed by your E.Application.
Generally, all files read at the startup and maintained in the server memory, need a full restart of the server.