You can use a dense feature detector, like the one implemented in C++: http://docs.opencv.org/modules/features2d/doc/common_interfaces_of_feature_detectors.html#densefeaturedetector
The thing is, I'm not sure if that has been ported to python yet. But, since the algorithm is not so hard, you could implement it yourself. Here is the implementation in C++:
void DenseFeatureDetector::detectImpl( const Mat& image, vector<KeyPoint>& keypoints, const Mat& mask ) const
{
float curScale = static_cast<float>(initFeatureScale);
int curStep = initXyStep;
int curBound = initImgBound;
for( int curLevel = 0; curLevel < featureScaleLevels; curLevel++ )
{
for( int x = curBound; x < image.cols - curBound; x += curStep )
{
for( int y = curBound; y < image.rows - curBound; y += curStep )
{
keypoints.push_back( KeyPoint(static_cast<float>(x), static_cast<float>(y), curScale) );
}
}
curScale = static_cast<float>(curScale * featureScaleMul);
if( varyXyStepWithScale ) curStep = static_cast<int>( curStep * featureScaleMul + 0.5f );
if( varyImgBoundWithScale ) curBound = static_cast<int>( curBound * featureScaleMul + 0.5f );
}
KeyPointsFilter::runByPixelsMask( keypoints, mask );
}
However, as you will notice, this implementation does not deal with the angle of the keypoints. That can be a problem if your images have rotation.