Python lifelines - ConvergenceWarning: Newton-Raphson failed to converge sufficiently in Cox prop hazard
https://datascience.stackexchange.com/questions/56608
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02-11-2019 - |
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When calling CoxPHFitter() on my full dataset I'm getting the following error:
Users/anaconda3/lib/python3.7/site-packages/lifelines/fitters/coxph_fitter.py:557: ConvergenceWarning: Newton-Rhapson failed to converge sufficiently in 50 steps.
warnings.warn("Newton-Rhapson failed to converge sufficiently in %d steps." % max_steps, ConvergenceWarning)
But I couldn't find how to increase number of steps.
I've also tried to play with the values of the params: step_size, enalizer and alpha - with no success.
This is the function that I'm running and the params:
def cox_proportional_hazard_model(data, survival_duration, survival_status, strata=None):
cph = CoxPHFitter(alpha=0.05, tie_method='Efron', penalizer=0.1, strata=None)
cph.fit(df=data,
duration_col=survival_duration, event_col=survival_status,
strata=strata, show_progress=True, step_size=0.1)
cph.print_summary()
return cph
and here is the output and the deltas:
Iteration 1: norm_delta = 22.95175, step_size = 0.1000, ll = -383.78983, newton_decrement = 224.62787, seconds_since_start = 0.0
Iteration 2: norm_delta = 8.59969, step_size = 0.0250, ll = -344.73687, newton_decrement = 100.90631, seconds_since_start = 0.1
Iteration 3: norm_delta = 8.00526, step_size = 0.0225, ll = -339.71541, newton_decrement = 95.05309, seconds_since_start = 0.1
Iteration 4: norm_delta = 7.61510, step_size = 0.0243, ll = -335.44970, newton_decrement = 90.63796, seconds_since_start = 0.1
Iteration 5: norm_delta = 7.29316, step_size = 0.0262, ll = -331.05741, newton_decrement = 86.53240, seconds_since_start = 0.2
Iteration 6: norm_delta = 7.02757, step_size = 0.0283, ll = -326.52929, newton_decrement = 82.69935, seconds_since_start = 0.2
Iteration 7: norm_delta = 6.80949, step_size = 0.0306, ll = -321.85618, newton_decrement = 79.10759, seconds_since_start = 0.2
Iteration 8: norm_delta = 6.63229, step_size = 0.0331, ll = -317.02892, newton_decrement = 75.73047, seconds_since_start = 0.3
Iteration 9: norm_delta = 6.49106, step_size = 0.0357, ll = -312.03837, newton_decrement = 72.54478, seconds_since_start = 0.3
Iteration 10: norm_delta = 6.38213, step_size = 0.0386, ll = -306.87533, newton_decrement = 69.52988, seconds_since_start = 0.3
Iteration 11: norm_delta = 6.30276, step_size = 0.0416, ll = -301.53059, newton_decrement = 66.66703, seconds_since_start = 0.3
Iteration 12: norm_delta = 6.25096, step_size = 0.0450, ll = -295.99496, newton_decrement = 63.93876, seconds_since_start = 0.4
Iteration 13: norm_delta = 6.22523, step_size = 0.0486, ll = -290.25932, newton_decrement = 61.32840, seconds_since_start = 0.4
Iteration 14: norm_delta = 6.22451, step_size = 0.0525, ll = -284.31480, newton_decrement = 58.81965, seconds_since_start = 0.4
Iteration 15: norm_delta = 6.24798, step_size = 0.0567, ll = -278.15291, newton_decrement = 56.39613, seconds_since_start = 0.5
Iteration 16: norm_delta = 6.29497, step_size = 0.0500, ll = -271.76578, newton_decrement = 54.04106, seconds_since_start = 0.5
Iteration 17: norm_delta = 6.35101, step_size = 0.0441, ll = -266.33229, newton_decrement = 52.14109, seconds_since_start = 0.5
Iteration 18: norm_delta = 6.40935, step_size = 0.0389, ll = -261.68076, newton_decrement = 50.57648, seconds_since_start = 0.6
Iteration 19: norm_delta = 6.46639, step_size = 0.0343, ll = -257.67951, newton_decrement = 49.26847, seconds_since_start = 0.6
Iteration 20: norm_delta = 6.52023, step_size = 0.0302, ll = -254.22460, newton_decrement = 48.16262, seconds_since_start = 0.6
Iteration 21: norm_delta = 6.57000, step_size = 0.0267, ll = -251.23237, newton_decrement = 47.21966, seconds_since_start = 0.7
Iteration 22: norm_delta = 6.61537, step_size = 0.0235, ll = -248.63436, newton_decrement = 46.41034, seconds_since_start = 0.7
Iteration 23: norm_delta = 6.65633, step_size = 0.0207, ll = -246.37393, newton_decrement = 45.71217, seconds_since_start = 0.7
Iteration 24: norm_delta = 6.69308, step_size = 0.0183, ll = -244.40374, newton_decrement = 45.10750, seconds_since_start = 0.8
Iteration 25: norm_delta = 6.72589, step_size = 0.0161, ll = -242.68394, newton_decrement = 44.58214, seconds_since_start = 0.8
Iteration 26: norm_delta = 6.75508, step_size = 0.0142, ll = -241.18077, newton_decrement = 44.12455, seconds_since_start = 0.8
Iteration 27: norm_delta = 6.78100, step_size = 0.0126, ll = -239.86547, newton_decrement = 43.72517, seconds_since_start = 0.9
Iteration 28: norm_delta = 6.80396, step_size = 0.0111, ll = -238.71344, newton_decrement = 43.37602, seconds_since_start = 0.9
Iteration 29: norm_delta = 6.82427, step_size = 0.0098, ll = -237.70355, newton_decrement = 43.07037, seconds_since_start = 0.9
Iteration 30: norm_delta = 6.84223, step_size = 0.0086, ll = -236.81763, newton_decrement = 42.80250, seconds_since_start = 1.0
Iteration 31: norm_delta = 6.85809, step_size = 0.0076, ll = -236.03994, newton_decrement = 42.56752, seconds_since_start = 1.0
Iteration 32: norm_delta = 6.87209, step_size = 0.0067, ll = -235.35688, newton_decrement = 42.36124, seconds_since_start = 1.0
Iteration 33: norm_delta = 6.88445, step_size = 0.0059, ll = -234.75663, newton_decrement = 42.18003, seconds_since_start = 1.1
Iteration 34: norm_delta = 6.89535, step_size = 0.0052, ll = -234.22893, newton_decrement = 42.02075, seconds_since_start = 1.1
Iteration 35: norm_delta = 6.90497, step_size = 0.0046, ll = -233.76482, newton_decrement = 41.88069, seconds_since_start = 1.1
Iteration 36: norm_delta = 6.91345, step_size = 0.0041, ll = -233.35650, newton_decrement = 41.75748, seconds_since_start = 1.2
Iteration 37: norm_delta = 6.92093, step_size = 0.0036, ll = -232.99717, newton_decrement = 41.64906, seconds_since_start = 1.2
Iteration 38: norm_delta = 6.92753, step_size = 0.0032, ll = -232.68085, newton_decrement = 41.55361, seconds_since_start = 1.2
Iteration 39: norm_delta = 6.93335, step_size = 0.0028, ll = -232.40235, newton_decrement = 41.46957, seconds_since_start = 1.3
Iteration 40: norm_delta = 6.93847, step_size = 0.0025, ll = -232.15707, newton_decrement = 41.39556, seconds_since_start = 1.3
Iteration 41: norm_delta = 6.94300, step_size = 0.0022, ll = -231.94104, newton_decrement = 41.33037, seconds_since_start = 1.3
Iteration 42: norm_delta = 6.94698, step_size = 0.0019, ll = -231.75071, newton_decrement = 41.27294, seconds_since_start = 1.4
Iteration 43: norm_delta = 6.95050, step_size = 0.0017, ll = -231.58303, newton_decrement = 41.22233, seconds_since_start = 1.4
Iteration 44: norm_delta = 6.95360, step_size = 0.0015, ll = -231.43526, newton_decrement = 41.17774, seconds_since_start = 1.4
Iteration 45: norm_delta = 6.95634, step_size = 0.0013, ll = -231.30504, newton_decrement = 41.13844, seconds_since_start = 1.5
Iteration 46: norm_delta = 6.95875, step_size = 0.0012, ll = -231.19026, newton_decrement = 41.10379, seconds_since_start = 1.5
Iteration 47: norm_delta = 6.96087, step_size = 0.0010, ll = -231.08909, newton_decrement = 41.07326, seconds_since_start = 1.5
Iteration 48: norm_delta = 6.96275, step_size = 0.0009, ll = -230.99991, newton_decrement = 41.04634, seconds_since_start = 1.6
Iteration 49: norm_delta = 6.96440, step_size = 0.0008, ll = -230.92129, newton_decrement = 41.02261, seconds_since_start = 1.6
Iteration 50: norm_delta = 6.96586, step_size = 0.0007, ll = -230.85198, newton_decrement = 41.00169, seconds_since_start = 1.7
Convergence failed. See any warning messages.
Concordance index of the model 0.9980554205153136
<lifelines.CoxPHFitter: fitted with 115 observations, 19 censored>
duration col = 'Survival from onset'
event col = 'survival status'
penalizer = 0.1
number of subjects = 115
number of events = 96
log-likelihood = -230.85
time fit was run = 2019-07-29 18:06:24 UTC
---
coef exp(coef) se(coef) z p -log2(p) lower 0.95 upper 0.95
hsa-miR-1-3p 0.00 1.00 0.00 0.10 0.92 0.12 -0.00 0.00
hsa-miR-101-3p 0.00 1.00 0.00 0.35 0.73 0.45 -0.00 0.01
hsa-miR-103a-3p 0.00 1.00 0.00 0.78 0.44 1.19 -0.00 0.00
hsa-miR-103b -0.00 1.00 0.00 -0.35 0.73 0.46 -0.01 0.01
hsa-miR-106b-3p -0.00 1.00 0.01 -0.10 0.92 0.12 -0.02 0.01
hsa-miR-107 0.00 1.00 0.01 0.11 0.91 0.13 -0.01 0.01
hsa-miR-10a-5p -0.00 1.00 0.02 -0.20 0.84 0.25 -0.04 0.03
hsa-miR-10b-5p -0.01 0.99 0.02 -0.34 0.73 0.45 -0.04 0.02
hsa-miR-122-5p 0.00 1.00 0.00 0.05 0.96 0.06 -0.00 0.00
hsa-miR-125a-5p -0.00 1.00 0.00 -0.22 0.83 0.27 -0.01 0.01
hsa-miR-125b-2-3p -0.00 1.00 0.01 -0.17 0.86 0.21 -0.01 0.01
hsa-miR-125b-5p -0.00 1.00 0.01 -0.29 0.77 0.38 -0.01 0.01
hsa-miR-126-3p 0.00 1.00 0.00 0.09 0.93 0.11 -0.00 0.00
hsa-miR-126-5p 0.00 1.00 0.00 0.29 0.77 0.38 -0.00 0.00
hsa-miR-1268b 0.01 1.01 0.02 0.41 0.68 0.56 -0.04 0.06
hsa-miR-127-3p 0.01 1.01 0.03 0.46 0.64 0.64 -0.04 0.07
hsa-miR-128-3p -0.00 1.00 0.01 -0.12 0.91 0.14 -0.03 0.03
hsa-miR-1287-5p -0.00 1.00 0.02 -0.02 0.98 0.03 -0.04 0.04
hsa-miR-1301-3p 0.00 1.00 0.03 0.03 0.98 0.03 -0.05 0.05
hsa-miR-1306-5p -0.01 0.99 0.02 -0.33 0.74 0.44 -0.05 0.04
hsa-miR-1307-3p -0.00 1.00 0.00 -0.21 0.83 0.27 -0.01 0.01
hsa-miR-1307-5p 0.00 1.00 0.03 0.04 0.96 0.05 -0.06 0.06
hsa-miR-130a-3p 0.01 1.01 0.03 0.22 0.82 0.28 -0.05 0.06
hsa-miR-133a-3p 0.00 1.00 0.00 0.08 0.94 0.09 -0.01 0.01
hsa-miR-133b -0.00 1.00 0.02 -0.17 0.87 0.21 -0.03 0.03
hsa-miR-134-5p -0.00 1.00 0.01 -0.26 0.80 0.33 -0.01 0.01
hsa-miR-139-3p 0.00 1.00 0.02 0.06 0.95 0.08 -0.03 0.03
hsa-miR-140-3p 0.00 1.00 0.00 0.20 0.84 0.25 -0.01 0.01
hsa-miR-140-5p 0.02 1.02 0.05 0.33 0.74 0.43 -0.09 0.12
hsa-miR-142-3p -0.00 1.00 0.00 -0.03 0.97 0.04 -0.00 0.00
hsa-miR-142-5p 0.00 1.00 0.00 0.01 0.99 0.01 -0.00 0.00
hsa-miR-143-3p -0.00 1.00 0.00 -0.09 0.93 0.10 -0.00 0.00
hsa-miR-144-3p -0.00 1.00 0.01 -0.21 0.83 0.26 -0.03 0.02
hsa-miR-144-5p -0.00 1.00 0.03 -0.09 0.93 0.11 -0.07 0.06
hsa-miR-145-5p 0.01 1.01 0.04 0.26 0.80 0.33 -0.07 0.09
hsa-miR-146a-5p 0.00 1.00 0.00 0.01 0.99 0.01 -0.00 0.00
hsa-miR-146b-5p 0.00 1.00 0.01 0.04 0.97 0.05 -0.02 0.02
hsa-miR-148a-3p 0.00 1.00 0.00 0.54 0.59 0.76 -0.00 0.00
hsa-miR-148b-3p -0.00 1.00 0.00 -0.50 0.62 0.69 -0.01 0.01
hsa-miR-150-5p -0.00 1.00 0.00 -0.25 0.81 0.31 -0.00 0.00
hsa-miR-151a-3p -0.00 1.00 0.00 -0.09 0.93 0.10 -0.00 0.00
hsa-miR-151b/151a-5p 0.00 1.00 0.02 0.22 0.82 0.28 -0.03 0.04
hsa-miR-152-3p -0.00 1.00 0.02 -0.20 0.84 0.25 -0.04 0.03
hsa-miR-155-5p 0.00 1.00 0.01 0.58 0.56 0.83 -0.01 0.01
hsa-miR-15a-5p 0.00 1.00 0.02 0.15 0.88 0.19 -0.03 0.03
hsa-miR-15b-5p -0.00 1.00 0.01 -0.11 0.91 0.13 -0.01 0.01
hsa-miR-16-2-3p -0.00 1.00 0.01 -0.26 0.80 0.33 -0.02 0.01
hsa-miR-16-5p 0.00 1.00 0.00 0.15 0.88 0.18 -0.00 0.00
hsa-miR-17-5p -0.01 0.99 0.02 -0.32 0.75 0.41 -0.04 0.03
hsa-miR-181a-2-3p -0.01 0.99 0.07 -0.08 0.94 0.09 -0.14 0.13
hsa-miR-181a-5p 0.00 1.00 0.00 0.13 0.90 0.16 -0.01 0.01
hsa-miR-181b-5p 0.02 1.02 0.03 0.67 0.51 0.98 -0.04 0.07
hsa-miR-182-5p -0.00 1.00 0.01 -0.02 0.98 0.03 -0.02 0.02
hsa-miR-183-5p 0.00 1.00 0.01 0.22 0.83 0.27 -0.02 0.02
hsa-miR-185-3p 0.00 1.00 0.05 0.09 0.93 0.10 -0.09 0.10
hsa-miR-185-5p 0.00 1.00 0.00 0.14 0.89 0.17 -0.01 0.01
hsa-miR-186-5p -0.00 1.00 0.01 -0.03 0.97 0.04 -0.02 0.02
hsa-miR-18a-5p 0.02 1.02 0.06 0.32 0.75 0.42 -0.09 0.13
hsa-miR-1908-5p -0.00 1.00 0.03 -0.14 0.89 0.16 -0.06 0.05
hsa-miR-190a-5p 0.00 1.00 0.04 0.13 0.90 0.15 -0.07 0.08
hsa-miR-191-5p -0.00 1.00 0.00 -0.47 0.64 0.65 -0.00 0.00
hsa-miR-192-5p 0.00 1.00 0.01 0.10 0.92 0.12 -0.02 0.02
hsa-miR-193a-5p -0.00 1.00 0.03 -0.11 0.91 0.14 -0.06 0.05
hsa-miR-194-5p -0.00 1.00 0.04 -0.09 0.93 0.11 -0.08 0.07
hsa-miR-195-5p -0.00 1.00 0.01 -0.28 0.78 0.36 -0.02 0.02
hsa-miR-196b-5p -0.01 0.99 0.02 -0.63 0.53 0.92 -0.06 0.03
hsa-miR-197-3p -0.00 1.00 0.02 -0.14 0.89 0.18 -0.04 0.03
hsa-miR-199a-3p -0.00 1.00 0.00 -0.54 0.59 0.76 -0.00 0.00
hsa-miR-199a-5p 0.02 1.02 0.04 0.42 0.68 0.56 -0.06 0.09
hsa-miR-199b-3p -0.00 1.00 0.00 -0.41 0.68 0.55 -0.01 0.01
hsa-miR-19a-3p 0.00 1.00 0.04 0.03 0.97 0.04 -0.08 0.09
hsa-miR-19b-3p 0.01 1.01 0.02 0.35 0.73 0.46 -0.03 0.04
hsa-miR-200a-3p 0.00 1.00 0.04 0.04 0.97 0.05 -0.07 0.07
hsa-miR-200b-3p 0.01 1.01 0.02 0.48 0.63 0.66 -0.03 0.04
hsa-miR-200c-3p 0.00 1.00 0.04 0.02 0.98 0.02 -0.08 0.08
hsa-miR-203a-3p -0.00 1.00 0.02 -0.24 0.81 0.30 -0.03 0.03
hsa-miR-205-5p -0.01 0.99 0.03 -0.18 0.86 0.22 -0.06 0.05
hsa-miR-206 0.00 1.00 0.00 0.13 0.90 0.16 -0.00 0.00
hsa-miR-20a-5p -0.00 1.00 0.01 -0.14 0.89 0.17 -0.02 0.02
hsa-miR-20b-5p -0.02 0.98 0.04 -0.45 0.65 0.61 -0.09 0.05
hsa-miR-21-5p 0.00 1.00 0.00 0.02 0.98 0.03 -0.00 0.00
hsa-miR-2110 -0.02 0.98 0.05 -0.39 0.70 0.52 -0.12 0.08
hsa-miR-22-3p 0.00 1.00 0.01 0.49 0.62 0.69 -0.01 0.02
hsa-miR-221-3p -0.00 1.00 0.00 -0.07 0.95 0.08 -0.00 0.00
hsa-miR-222-3p -0.00 1.00 0.01 -0.13 0.90 0.16 -0.02 0.02
hsa-miR-223-3p 0.00 1.00 0.00 0.46 0.64 0.64 -0.00 0.00
hsa-miR-223-5p 0.00 1.00 0.01 0.12 0.91 0.14 -0.03 0.03
hsa-miR-23a-3p 0.00 1.00 0.00 0.03 0.98 0.03 -0.01 0.01
hsa-miR-23b-3p 0.01 1.01 0.01 0.40 0.69 0.53 -0.02 0.03
hsa-miR-24-3p -0.00 1.00 0.00 -0.03 0.97 0.04 -0.01 0.01
hsa-miR-25-3p -0.00 1.00 0.00 -0.01 1.00 0.01 -0.00 0.00
hsa-miR-26a-5p 0.00 1.00 0.00 0.05 0.96 0.06 -0.00 0.00
hsa-miR-26b-5p -0.00 1.00 0.00 -0.17 0.87 0.20 -0.00 0.00
hsa-miR-27a-3p -0.00 1.00 0.01 -0.27 0.78 0.35 -0.03 0.02
hsa-miR-27b-3p -0.00 1.00 0.01 -0.21 0.83 0.26 -0.01 0.01
hsa-miR-28-3p 0.00 1.00 0.01 0.05 0.96 0.06 -0.02 0.02
hsa-miR-29a-3p -0.00 1.00 0.00 -0.58 0.56 0.82 -0.01 0.00
hsa-miR-29b-3p -0.00 1.00 0.03 -0.15 0.88 0.19 -0.06 0.05
hsa-miR-29c-3p -0.00 1.00 0.01 -0.18 0.86 0.22 -0.01 0.01
hsa-miR-29c-5p -0.00 1.00 0.05 -0.02 0.98 0.02 -0.09 0.09
hsa-miR-30a-5p -0.00 1.00 0.01 -0.10 0.92 0.12 -0.01 0.01
hsa-miR-30b-5p -0.01 0.99 0.04 -0.12 0.90 0.15 -0.09 0.08
hsa-miR-30c-5p 0.00 1.00 0.02 0.15 0.88 0.19 -0.03 0.04
hsa-miR-30d-5p 0.00 1.00 0.00 0.19 0.85 0.24 -0.00 0.00
hsa-miR-30e-3p -0.00 1.00 0.01 -0.14 0.89 0.18 -0.02 0.02
hsa-miR-30e-5p -0.00 1.00 0.00 -0.55 0.59 0.77 -0.01 0.00
hsa-miR-3135b 0.00 1.00 0.01 0.14 0.89 0.17 -0.02 0.03
hsa-miR-3168 0.00 1.00 0.00 0.30 0.76 0.39 -0.00 0.00
hsa-miR-320a -0.00 1.00 0.00 -0.04 0.97 0.04 -0.00 0.00
hsa-miR-320b -0.00 1.00 0.01 -0.23 0.82 0.29 -0.03 0.02
hsa-miR-320c -0.00 1.00 0.02 -0.14 0.89 0.17 -0.05 0.04
hsa-miR-323b-3p 0.04 1.04 0.05 0.72 0.47 1.09 -0.06 0.13
hsa-miR-324-5p -0.01 0.99 0.04 -0.16 0.88 0.19 -0.07 0.06
hsa-miR-326 -0.00 1.00 0.03 -0.12 0.90 0.15 -0.06 0.05
hsa-miR-328-3p -0.00 1.00 0.01 -0.06 0.95 0.07 -0.01 0.01
hsa-miR-335-5p -0.01 0.99 0.02 -0.50 0.62 0.69 -0.04 0.03
hsa-miR-339-3p -0.00 1.00 0.04 -0.05 0.96 0.05 -0.07 0.07
hsa-miR-339-5p 0.00 1.00 0.01 0.42 0.67 0.57 -0.01 0.02
hsa-miR-340-5p 0.01 1.01 0.02 0.34 0.73 0.45 -0.04 0.05
hsa-miR-342-3p -0.00 1.00 0.00 -0.05 0.96 0.06 -0.00 0.00
hsa-miR-345-5p 0.00 1.00 0.05 0.02 0.98 0.03 -0.09 0.10
hsa-miR-34a-5p 0.00 1.00 0.03 0.16 0.87 0.20 -0.05 0.06
hsa-miR-361-3p 0.01 1.01 0.03 0.44 0.66 0.61 -0.04 0.06
hsa-miR-361-5p 0.00 1.00 0.01 0.38 0.70 0.50 -0.02 0.03
hsa-miR-3613-3p 0.01 1.01 0.02 0.32 0.75 0.41 -0.03 0.04
hsa-miR-3615 0.00 1.00 0.01 0.24 0.81 0.30 -0.02 0.03
hsa-miR-363-3p 0.01 1.01 0.02 0.44 0.66 0.60 -0.03 0.05
hsa-miR-3687 0.02 1.02 0.04 0.62 0.54 0.90 -0.05 0.10
hsa-miR-370-3p -0.00 1.00 0.02 -0.11 0.91 0.14 -0.03 0.03
hsa-miR-374a-5p -0.01 0.99 0.04 -0.37 0.71 0.49 -0.09 0.06
hsa-miR-374b-5p -0.02 0.98 0.08 -0.29 0.77 0.38 -0.17 0.13
hsa-miR-375 0.00 1.00 0.01 0.07 0.94 0.09 -0.02 0.02
hsa-miR-378a-3p 0.00 1.00 0.01 0.11 0.92 0.13 -0.02 0.03
hsa-miR-378c 0.02 1.02 0.04 0.40 0.69 0.53 -0.06 0.10
hsa-miR-379-5p 0.00 1.00 0.02 0.21 0.83 0.26 -0.03 0.04
hsa-miR-381-3p 0.00 1.00 0.04 0.12 0.90 0.15 -0.07 0.08
hsa-miR-382-5p 0.00 1.00 0.01 0.19 0.85 0.24 -0.01 0.01
hsa-miR-3940-3p -0.01 0.99 0.02 -0.26 0.79 0.33 -0.04 0.03
hsa-miR-3974 -0.00 1.00 0.02 -0.21 0.83 0.26 -0.03 0.03
hsa-miR-409-3p -0.00 1.00 0.01 -0.48 0.63 0.67 -0.01 0.01
hsa-miR-423-3p -0.00 1.00 0.01 -0.72 0.47 1.08 -0.01 0.01
hsa-miR-423-5p 0.00 1.00 0.00 0.15 0.88 0.19 -0.00 0.00
hsa-miR-425-3p 0.00 1.00 0.02 0.08 0.94 0.09 -0.04 0.05
hsa-miR-425-5p -0.00 1.00 0.00 -0.21 0.84 0.26 -0.00 0.00
hsa-miR-4254 -0.00 1.00 0.01 -0.30 0.77 0.38 -0.03 0.02
hsa-miR-4286 0.03 1.03 0.06 0.56 0.57 0.80 -0.08 0.14
hsa-miR-431-5p -0.00 1.00 0.02 -0.15 0.88 0.18 -0.04 0.03
hsa-miR-432-5p 0.00 1.00 0.00 0.28 0.78 0.35 -0.00 0.01
hsa-miR-4433a-3p -0.00 1.00 0.03 -0.01 0.99 0.01 -0.06 0.06
hsa-miR-4433b-5p 0.00 1.00 0.01 0.20 0.84 0.25 -0.01 0.01
hsa-miR-4446-3p 0.01 1.01 0.04 0.24 0.81 0.30 -0.07 0.09
hsa-miR-4451 -0.00 1.00 0.02 -0.00 1.00 0.00 -0.04 0.04
hsa-miR-4454 -0.01 0.99 0.03 -0.28 0.78 0.36 -0.08 0.06
hsa-miR-451a 0.00 1.00 0.00 0.23 0.82 0.29 -0.00 0.00
hsa-miR-454-3p -0.00 1.00 0.02 -0.12 0.91 0.14 -0.05 0.04
hsa-miR-4655-5p -0.00 1.00 0.01 -0.05 0.96 0.06 -0.02 0.02
hsa-miR-4732-5p 0.00 1.00 0.02 0.02 0.98 0.03 -0.03 0.03
hsa-miR-483-5p 0.01 1.01 0.01 0.50 0.62 0.70 -0.02 0.03
hsa-miR-484 0.00 1.00 0.00 0.11 0.91 0.13 -0.01 0.01
hsa-miR-485-3p -0.00 1.00 0.02 -0.11 0.91 0.14 -0.03 0.03
hsa-miR-485-5p 0.01 1.01 0.05 0.16 0.87 0.19 -0.10 0.12
hsa-miR-486-3p 0.00 1.00 0.00 0.13 0.89 0.16 -0.00 0.00
hsa-miR-486-5p 0.00 1.00 0.00 0.09 0.93 0.11 -0.00 0.00
hsa-miR-487b-3p -0.00 1.00 0.05 -0.04 0.97 0.05 -0.10 0.09
hsa-miR-501-3p 0.02 1.02 0.04 0.42 0.68 0.57 -0.07 0.10
hsa-miR-532-5p -0.01 0.99 0.04 -0.34 0.73 0.45 -0.08 0.06
hsa-miR-548ad-3p 0.00 1.00 0.02 0.17 0.87 0.21 -0.03 0.04
hsa-miR-548ap-5p/548j-5p -0.00 1.00 0.04 -0.10 0.92 0.12 -0.09 0.08
hsa-miR-574-3p 0.01 1.01 0.02 0.25 0.80 0.32 -0.03 0.04
hsa-miR-584-5p 0.00 1.00 0.00 0.53 0.60 0.74 -0.00 0.01
hsa-miR-625-3p -0.00 1.00 0.00 -0.03 0.97 0.04 -0.01 0.01
hsa-miR-625-5p 0.01 1.01 0.02 0.29 0.77 0.37 -0.03 0.04
hsa-miR-628-3p -0.00 1.00 0.03 -0.03 0.97 0.04 -0.07 0.07
hsa-miR-629-5p -0.00 1.00 0.02 -0.21 0.83 0.26 -0.03 0.03
hsa-miR-652-3p 0.00 1.00 0.04 0.11 0.92 0.13 -0.08 0.09
hsa-miR-654-3p -0.01 0.99 0.02 -0.26 0.80 0.33 -0.05 0.04
hsa-miR-660-5p -0.01 0.99 0.02 -0.76 0.45 1.16 -0.05 0.02
hsa-miR-664a-5p -0.01 0.99 0.03 -0.26 0.79 0.34 -0.06 0.05
hsa-miR-671-3p -0.01 0.99 0.06 -0.17 0.87 0.21 -0.13 0.11
hsa-miR-671-5p 0.02 1.02 0.05 0.29 0.77 0.38 -0.09 0.12
hsa-miR-6728-5p -0.00 1.00 0.01 -0.13 0.89 0.16 -0.03 0.02
hsa-miR-6749-5p -0.01 0.99 0.01 -0.50 0.62 0.70 -0.04 0.02
hsa-miR-6787-5p -0.00 1.00 0.03 -0.19 0.85 0.24 -0.06 0.05
hsa-miR-6852-5p -0.01 0.99 0.06 -0.15 0.88 0.19 -0.12 0.10
hsa-miR-6890-5p 0.00 1.00 0.02 0.10 0.92 0.12 -0.04 0.05
hsa-miR-7-5p 0.01 1.01 0.02 0.38 0.70 0.51 -0.03 0.05
hsa-miR-744-5p -0.00 1.00 0.00 -0.07 0.95 0.08 -0.01 0.01
hsa-miR-760 0.03 1.03 0.05 0.49 0.62 0.69 -0.08 0.13
hsa-miR-769-5p 0.00 1.00 0.06 0.02 0.99 0.02 -0.11 0.11
hsa-miR-92a-3p 0.00 1.00 0.00 0.17 0.87 0.20 -0.00 0.00
hsa-miR-92b-3p -0.00 1.00 0.01 -0.08 0.94 0.09 -0.02 0.02
hsa-miR-93-5p -0.00 1.00 0.00 -0.30 0.76 0.39 -0.00 0.00
hsa-miR-941 -0.03 0.97 0.04 -0.65 0.51 0.96 -0.12 0.06
hsa-miR-98-5p 0.01 1.01 0.01 0.51 0.61 0.71 -0.02 0.03
hsa-miR-99a-5p 0.00 1.00 0.02 0.23 0.82 0.28 -0.04 0.05
hsa-miR-99b-5p 0.00 1.00 0.01 0.13 0.90 0.15 -0.01 0.01
---
Concordance = 1.00
Log-likelihood ratio test = 305.88 on 196 df, -log2(p)=20.20
/Users/nancy/anaconda3/lib/python3.7/site-packages/lifelines/fitters/coxph_fitter.py:557: ConvergenceWarning: Newton-Rhapson failed to converge sufficiently in 50 steps.
warnings.warn("Newton-Rhapson failed to converge sufficiently in %d steps." % max_steps, ConvergenceWarning)
<lifelines.CoxPHFitter: fitted with 115 observations, 19 censored>
No hay solución correcta
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