How to apply Panels layouts for CiviCRM pages

Question

For CiviCRM pages Events and Contributions that has paths of e.g.

www.site.com/civicrm/contribute/transact?reset=1&id=1
www.site.com/civicrm/event/register?id=23&reset=1

And so on.

Problem is that you need to copy paste custom .php files and folders in themes dir for each form to apply custom styling, e.g. have right side and left side columns and display custom content. E.g. left side column texts and infos, descriptions and right side column contains the registration form/payments.

I can't figure out how to do that without copying multiple folders for each form and editing it each time to match the page ID.

I'm looking at the Panels and it doesn't have CiviCRM content as nodes content type to be applied and filtered out in the panels variant and etc.

Or not possible?