It depends of your situation. If you don't want to listen some event, when module doesn't work, you can subscribe to module "stop" event and execute off for all necessary events.
module.on("stop", function(){
App.vent.off(someMethods);
});
As usuall, view doesn't use global event aggregation. But if you use, you shuold use
this.listenTo( App.vent, "someEvent", function(){...} )
and then Marionette remove this handler.