Got it.
Set objIADS = GetObject("WinNT:").OpenDSObject("WinNT://domain", "Administrator", sDomainPassword, ADS_SECURE_AUTHENTICATION)
Set objIADSUser = objIADS.GetObject("user", sUserID)
objIADSUser.ChangePassword sOldPassword, sNewPassword
'Alternatively: objIADSUser.SetPassword sNewPassword
objIADSUser.SetInfo