You can use any of the available drivers. All of them provide a callback based approach, common in Node.js.
If you are looking for a native driver in Node.js for Cassandra without a thrift dependency, you should consider DataStax Node.js driver for Cassandra.
Example:
var cassandra = require('cassandra-driver');
var client = new cassandra.Client({contactPoints: ['host1', 'host2']});
var query = 'SELECT email, last_name FROM user_profiles WHERE key=?';
client.execute(query, ['guy'], function(err, result) {
console.log('got user profile with email ' + result.rows[0].email);
});
Disclaimer: I'm the author of node-cassandra-cql and contributor in the DataStax Node.js driver for Cassandra.
UPDATE: Recommended to DataStax driver instead of node-cassandra-cql