We are adding propery 'POST_TO_URI' to our synapse API configuration in order to make the outgoing URL a complete URL [1]. This is useful when sending the messages through a proxy server. You can remove that property by modifying your API in AM_HOME/repository/deployment/server/synapse-configs/default/api/ directory. Remove the below property in your relevant APIs which sending requests to such backend servers.
<property name="POST_TO_URI" value="true" scope="axis2"/>
[1]https://docs.wso2.org/display/ESB460/HTTP+Transport+Properties