After going through some iterations on this in the comments, in most cases you won't need to do node specific customizations of cassandra.yaml. The one I tend to set (because I have multiple interfaces in many of my machines) is listen_address, but as https://stackoverflow.com/users/56076/don-branson points out, if you leave that blank the system will sort that one out for you.
Check http://www.datastax.com/documentation/datastax_enterprise/4.0/datastax_enterprise/deploy/deploySingleDC.html for more current information just in case.