'Probably' - it would be nice it you added a few examples to the question (requests and associated responses).
Sending the requests is fine, though you will need to explicitly specify the path / route name to use.
For the response, you will most likely need to use an RKDynamicMapping
which will inspect the incoming data and return the appropriate mapping to use.
If you can't tell the 'type' from the response data (instead, you can only tell because of the URL that was requested) then you may need to try mapping into all types and rejecting invalid content using KVC validation, or you might want to change your data model (not enough information in the question to determine which...).