Ok, so with this type of solution you're likely going to have to do a bunch of reflection to get it to work dynamically.
string SelectField = cb1.Name.Substring(2);
ParameterExpression pe = Expression.Parameter(typeof(Item), "p");
First you have to invoke the lambda method without knowing the complete return type. The return type is Expression<Func<Item, ?>>
(with the question mark being a placeholder for the property type.
var propertyType = typeof(Item).GetProperty(SelectField).GetGetMethod().ReturnType;
var lambdaMethodParamType = typeof(Func<,>).MakeGenericType(typeof(Item), propertyType);
var lambdaMethod = typeof(Expression).GetMethods().First(x => x.Name == "Lambda" && x.IsGenericMethod).MakeGenericMethod(lambdaMethodParamType);
var expr = lambdaMethod.Invoke(null, new object[] { Expression.Property(pe, SelectField), new ParameterExpression[] { pe } });
Then we have to invoke the select method in a similar fashion because the property type isn't know until runtime.
var selectMethod = typeof(Queryable).GetMethods().First(x => x.Name == "Select").MakeGenericMethod(typeof(Item), propertyType);
var query = (IQueryable)selectMethod.Invoke(null, new object[] { MyContext.Items, expr });
I don't know what you're doing with the query variable so I can't provide any further guidance with that at this time. Again, in this example we don't know what type will be contained in the collection until runtime because it is a collection of the property values.
FYI: My method for selecting the correct lambda and select was a total hack. You really should create a more robust search method examing the signature more completely to ensure you've found the correct method you are needing. I can provide a better example later if you need it when I have more time.