In your Genero Studio configuration, there should be a list of environment sets listed. One of them should be for your backend. Make sure it is configured properly. Then make sure it is checked for your preferred configuration.
There are different ways to connect to a DB, make sure you review the following doc:
http://www.4js.com/online_documentation/fjs-fgl-manual-html/User/Connections.html
From there, I would write a simple BDL program to test:
main
define mystatus smallint
database mydb # this is where you can adapt based on your preferred connection method
end main
Make sure that in your environment set, Debug is check since this will provide SQL driver debug info (FGLSQLDEBUG=9)
From there, check your output panel and see what needs to be configured
When the connection is working, you can extract a schema (needed at compile time) or maybe you already have a schema (.sch file) already created that you simply want to import