It's doable. Without media queries you will be limited to how involved you get. This would work well if your columns were of equal width. I'm not sure how your design is, but without a media query it will be challenging to make even columns. Here is some roughed out HTML to get you going.
<!doctype html>
<html>
<head>
<meta charset="UTF-8">
<title>Untitled Document</title>
</head>
<body marginheight="0" marginwidth="0" leftmargin="0" topmargin="0">
<table width="100%" border="0" cellspacing="0" cellpadding="0">
<tr>
<td width="100%" align="center" valign="top">
<table border="0" cellpadding="0" cellspacing="0" width="100%" style="max-width: 650px;">
<tr>
<td width="650">
<table cellpadding="0" cellspacing="0">
<tr>
<td colspan="1" style="width: 100%;"> --banner image here-- </td>
</tr>
</table>
<table align="left" width="320">
<tr>
<td align="left" valign="top" width="320" bgcolor="#00CC99" style="padding-left: 10px; padding-right: 10px;"> --content goes here-- </td>
</tr>
</table>
<table align="left" width="180">
<tr>
<td align="left" valign="top" width="180" bgcolor="#99CC33" style="padding-left: 10px; padding-right: 10px;"> --list of links-- </td>
</tr>
</table>
</td>
</tr>
</table>
</td>
</tr>
</table>
</body>