There is no debugging feature in Komodo Edit but you can just run the current file by creating a Run Command:
- go to Toolbox -> Add -> New Command...
- in the top field enter the name 'Run Python file'
- in the 'Command' field enter this text:
%(python) %F
- (optional) click on the 'Key Binding' tab and assign a key command to this command
- click Ok.
You should now have a new Run Command in your toolbox called 'Run Python file'; when you double-click on it the command should run the current Python script open in the editor and display the output in the Command Output pane.
For more on Run Commands:
http://aspn.activestate.com/ASPN/docs/Komodo/4.2/komodo-doc-run.html#run...