You actually don't want to change the font of the whole cell but you to change a portion of the text in the cell I take it. You'll still need to retrieve the cell range and then adjust the characters within that range. here is an example where it's just adjusting the first cell. A1.
If you wanted to change the whole cell range to be superscript it would be done like this currentRange.Font.Superscript = true;
void Main()
{
var app = new Application();
app.Visible = true;
var workbook = app.Workbooks.Add(1);
Sheets excelSheets = workbook.Worksheets;
string currentSheet = "Sheet1";
Worksheet worksheet1 = (Worksheet)excelSheets.get_Item(currentSheet);
worksheet1.Cells[1, 1] = "April 1st";
worksheet1.Cells[1, 2] = "April 2nd";
worksheet1.Cells[1, 3] = "April 3rd";
worksheet1.Cells[1, 4] = "April 4th";
// fill in the starting and ending range programmatically this is just an example.
string startRange = "A1";
string endRange = "A1";
Range currentRange = worksheet1.get_Range(startRange , endRange );
var text = currentRange.Text.ToString();
int length = text.Length;
int index = 0;
if(text.Contains("st"))
{
index =text.IndexOf("st");
}
//The other checks for "nd", "rd", "th" obviously check to see a # precedes these.
if(index > 0)
{
currentRange.get_Characters( index+1, 2).Font.Superscript = true;
}
}