When you access memory, you're accessing the process address space.
The process address space is divided into pages (typically 4 KB on x86). These are virtual pages: their contents are held elsewhere. The kernel manages a mapping from virtual pages to their contents. Contents can be provided by:
A physical page, for pages that are currently backed by physical RAM. Accesses to these happen directly (via the memory management hardware).
A page that's been swapped out to disk. Accessing this will cause a page fault, which the kernel handles. It needs to fill a physical page with the on-disk contents, so it finds a free physical page (perhaps swapping that page's contents out to disk), reads in the contents from disk, and updates the mapping to state that "virtual page X is in physical page Y".
A file (i.e. a memory mapped file).
Hardware devices (i.e. hardware device registers). These don't usually concern us in user space.
Suppose that we have a 4 GB virtual address space, split into 4 KB pages, giving us 1048576 virtual pages. Some of these will be mapped by the kernel; others will not. When the process starts (i.e. when main() is invoked), the virtual address space will contain, amongst other things:
Program code. These pages are usually readable and executable.
Program data (i.e. for initialised variables). This usually has some read-only pages and some read-write pages.
Code and data from libraries that the program depends on.
Some pages for the stack.
These things are all mapped as pages in the 4 GB address space. You can see what's mapped by looking at /proc/(pid)/maps, as one of the comments has pointed out. The precise contents and location of these pages depend on (a) the program in question, and (b) address space layout randomisation (ASLR), which makes locations of things harder to guess, thereby making certain security exploitation techniques more difficult.
You can access any particular location in memory by defining a pointer and dereferencing it:
*(unsigned char *)0x12345678
If this happens to point to a mapped page, and that page is readable, then the access will succeed and yield whatever's mapped at that address. If not, then you'll receive a SIGSEGV from the kernel. You could handle that (which is useful in some cases, such as JIT compilers), but normally you don't, and the process will be terminated. As noted above, due to ASLR, if you do this in a program and run the program several times then you'll get non-deterministic results for some addresses.