You cannot make this work with Hyperterminal either. The sandbox in which Store apps operate explicitly defeats any attempt a Store app might make to use a inter-process communication mechanism.
Do ask yourself if it makes sense to publish such an application in the Store. The odds that a user that visits the store will have the required hardware to make your app useful are extremely slim. These kind of apps will stay desktop apps for a long time to come. If the manufacturer of the device sees a market opportunity to get his device operating in store apps then he'll create a Store compatible driver for it. But that's up to them, you cannot do this yourself.