It's fairly hacky, but as you said it's the application main loop, I assume it's in a called-once function, so the following should work:
struct RunOnce {
template <typename T>
RunOnce(T &&f) { f(); }
};
:::
while(true)
{
:::
static RunOnce a([]() { your_code });
:::
static RunOnce b([]() { more_once_only_code });
:::
}