Here is the way I do it. List comprehension to the rescue!
>>> import multiprocessing
>>> m = multiprocessing.Manager()
>>> lst = m.list()
>>> lst.append(0)
>>> lst.append(1)
>>> lst.append(2)
>>> lst
<ListProxy object, typeid 'list' at 0x3397970>
>>> lst[:]
[0, 1, 2]
>>> lst[:] = []
>>> lst
<ListProxy object, typeid 'list' at 0x3397970>
>>> lst[:]
[]
>>>
so
>>> lst[:] = []
does it :)