What you're looking for is called a Pairing function.
The following illustration from the German wikipedia page clearly shows how it works:
Implemented in Ruby:
def cantor_pairing(n, m)
(n + m) * (n + m + 1) / 2 + m
end
(0..5).map do |n|
(0..5).map do |m|
cantor_pairing(n, m)
end
end
=> [[ 0, 2, 5, 9, 14, 20],
[ 1, 4, 8, 13, 19, 26],
[ 3, 7, 12, 18, 25, 33],
[ 6, 11, 17, 24, 32, 41],
[10, 16, 23, 31, 40, 50],
[15, 22, 30, 39, 49, 60]]
Note that you will need to store the result of this pairing in a datatype with as many bits as both your input numbers put together. (If both input numbers are 32-bit, you will need a 64-bit datatype to be able to store all possible combinations, obviously.)