Check out the documentation for apc.stat
:
http://www.php.net/manual/en/apc.configuration.php#ini.apc.stat
This defaults to on, forcing APC to stat (check) the script on each request to determine if it has been modified. If it has been modified it will recompile and cache the new version. If this setting is off, APC will not check, which usually means that to force APC to recheck files, the web server will have to be restarted or the cache will have to be manually cleared.