I'm not sure how complex your code is, but if each movieclip has MOUSE_UP event handler - some function, you could indeed use removeEventListener MOUSE_UP function. For instance:
var mc:MovieClip = new MovieClip();
mc.addEventListener( MouseEvent.MOUSE_UP, onMU );
function onMU(e:MouseEvent){
var target = MovieClip(e.currentTarget);
target.removeEventListener( MouseEvent.MOUSE_UP, onMU );
}
This way you can have multiple movieclips and remove listeners without knowing object name.
Alternatively you could modify your code to add aray of all added events and then listen to REMOVE_FROM_STAGE event. Something like this:
var mc:MovieClip = new MovieClip();
mc.events = [];
mc.events.push( { evt: MouseEvent.MOUSE_UP, fn: onMU } );
mc.addEventListener( MouseEvent.MOUSE_UP, onMU } )
//or use events array reference to keep events and functions in one place.
//when object is removed you can iterate through events array and automatically remove
//all listeners
Another alternative would be to create Class that extends MovieClip - but since your code is huge you probably don't want to do that.
You can also look on Robert Penner's Signals library, which is interesting alternative to AS3 events. (https://github.com/robertpenner/as3-signals)