Quick update : I have solved this. You will have to:
- Generate TLB for INetCfg interface
- Import it into Python using Comtypes
- Create a COM object of INetCg instance
- Acquire write lock
- FindComponent for a given NIC
- Enumarate protocol for that given NIC
- Bind/Unbind protocol from given NIC
- Apply changes
- ReleaseLock
I will elaborate it as soon as I have time for this You will have to get acquainted of comtypes to easily implement this.