I am not sure whether this is right but can you do this ?
In the current application store the Server.MapPath value and then replace the current application name with "Myapplication" and then add the trailing path. Something like this
string path1 = Server.MapPath("");
path1.Replace("Application1", "Myapplication"); //Considering "Application1" is the name of your current application
path1 += "/Images/Landing/bottom_banner/";
HttpPostedFileBase photo = Request.Files["adup"];
if (photo.ContentLength != 0)
{
string lastPart = photo.FileName.Split('\\').Last();
Random random = new Random();
int rno = random.Next(0, 1000);
photo.SaveAs(path1 + rno + lastPart);
}
There might be a permission problem with this one. I have not checked it. If it works please let me know.