Try the following settings if you still have not got this sorted out yet:
$base_url="http://www.domain.com/cms"; // base url of site. If you prefer relative urls leave empty --> No trailing slash
// The upload directory will be a dir you have created for the files to be uploaded to, ie: localhost/cms/app/webroot/files/cms --> this file must have write permission.
$upload_dir = '/app/webroot/files/cms/'; // path from base_url to base of upload folder --> write permission (chmod = 755)
$current_path = '../../../../files/cms/'; // relative path from filemanager folder to upload folder (you are missing one "../")
// The thumbs folder located in tinymce/plugins/filemanager/thumbs must also have write permission (chmod = 755)
That should do it