dart2js is able to perform optimizations that would not normally be manually added in JavaScript code.
There is nothing particularly special about Dart being the source language in this case: any automated tool that generates JavaScript should be able to do this, for instance the GWT compiler (Java to JavaScript) does this as well. Of course, you can run automated tools on JavaScript source to generate better JavaScript as well, this is what the Closure compiler does.
Technically, you can manually achieve the same speed with handwritten JavaScript if you know all the tricks.