Use a Global Hotkey. That way you don't have to worry about your Application having focus. A good example for VB.Net is here:
http://www.kirsbo.com/How_to_add_global_hotkeys_to_applications_in_VB.NET
To summarise. Define a HotKey class:
Public Class Hotkey
#Region "Declarations - WinAPI, Hotkey constant and Modifier Enum"
''' <summary>
''' Declaration of winAPI function wrappers. The winAPI functions are used to register / unregister a hotkey
''' </summary>
Public Declare Function RegisterHotKey Lib "user32" _
(ByVal hwnd As IntPtr, ByVal id As Integer, ByVal fsModifiers As Integer, ByVal vk As Integer) As Integer
Public Declare Function UnregisterHotKey Lib "user32" (ByVal hwnd As IntPtr, ByVal id As Integer) As Integer
Public Const WM_HOTKEY As Integer = &H312
Enum KeyModifier
None = 0
Alt = &H1
Control = &H2
Shift = &H4
Winkey = &H8
End Enum 'This enum is just to make it easier to call the registerHotKey function: The modifier integer codes are replaced by a friendly "Alt","Shift" etc.
#End Region
#Region "Hotkey registration, unregistration and handling"
Public Shared Sub registerHotkey(ByRef sourceForm As Form, ByVal triggerKey As String, ByVal modifier As KeyModifier)
RegisterHotKey(sourceForm.Handle, 1, modifier, Asc(triggerKey.ToUpper))
End Sub
Public Shared Sub unregisterHotkeys(ByRef sourceForm As Form)
UnregisterHotKey(sourceForm.Handle, 1) 'Remember to call unregisterHotkeys() when closing your application.
End Sub
Public Shared Sub handleHotKeyEvent(ByVal hotkeyID As IntPtr)
MsgBox("The hotkey was pressed")
End Sub
#End Region
End Class
Then add the following Sub to your main form:
'System wide hotkey event handling
Protected Overrides Sub WndProc(ByRef m As System.Windows.Forms.Message)
If m.Msg = Hotkey.WM_HOTKEY Then
Hotkey.handleHotKeyEvent(m.WParam)
End If
MyBase.WndProc(m)
End Sub
Then register a HotKey in the startup code for your form:
Hotkey.RegisterHotKey(Me, "X", Hotkey.KeyModifier.Alt)
The first parameter is the form, the second is the key to be handled and the third is the modifier key. Once this Hotkey is registered it will trigger code in HotKey.handleHotKeyEvent
.
You can then use some sort of Callback to trigger a method in the calling form itself if you so desire.