I'd start by having a look at the documentation.
The method is define as such:
link_to(name = nil, options = nil, html_options = nil, &block)
So, yes. You can.
UPDATE:
As requested, here's an example:
link_args = {remote: true, data: {disable_with: 'loading'}, class: 'btn'}
link_to 'User Profile', @user, link_args