Element element = document.select("div.thumb-box thumb-160").first();
you have to use .
(dot) for every class
Element element = document.select("div.thumb-box.thumb-160").first();
Besides it is rather straight forward do select like this
Element element = document.select("div.thumb-box.thumb-160:eq(0) a").first();
This yould yet you anchor element out of the box