A bit tedious but fairly simple with a helper column, with =IF(COUNTIF(A:A,A2)=COUNTIFS(B:B,"<>R3552S",A:A,A2),A2,"")
in it and copied down (assuming Freezer Account is in ColumnA Row1 and no gaps). Add a label to the helper column (say E in ColumnE) and select it, Data > Sort & Filter - Advanced, Copy to another location (say G1), check Unique records only. Delete G1 and Column E and sort ColumnF.
Edit re supplementary
The formula and process is relatively cumbersome even for a single SKU exclusion but seemed to match the question's requirement better than a PivotTable would have. However where there are two exclusions (or even perhaps more) a PivotTable is very much simpler and more 'powerful', though it gives visual results rather than a list of exclusions:
.
The pale blue is the original answer and the darker blue the answer to the supplemental addition, so combined that is F0000563
. The 'power' comes from the same table offering answers to many more questions also. For example take in account 2 SKU's could mean just F0000563
("Which have neither?") as I have assumed but the answer (all four Freezer Accounts) is also evident for "Which do not have both?"