Base-64 could be an encoding of anything. If you know it's an encoding of an ASCII string, you could do this:
var bytes = Convert.FromBase64String(u);
var text = System.Text.Encoding.UTF8.GetString(bytes, 0, bytes.Length);
If it's an encoding of a Unicode string (you weren't specific), you could do this:
var bytes = Convert.FromBase64String(u);
var text = System.Text.Encoding.Unicode.GetString(bytes, 0, bytes.Length);