https://docs.djangoproject.com/en/dev/topics/http/shortcuts/#get-object-or-404
Note: As with get(), a MultipleObjectsReturned exception will be raised if more than one object is found.
edit:
def my_view(request):
try:
my_object = get_object_or_404(MyModel, something=1)
except MyModel.MultipleObjectsReturned:
# Maybe do something.
raise Http404