Using a combination of what djc wrote and some of my tinkering here's the working version so that:
www.mysite.com (wordpress site loads correctly)(mod_php)
www.mysite.com/reviewboard (reviewboard site loads correctly)(mod_wsgi)
Important make sure you clear your browser cache every time you restart your apache server as I kept falling into the trap of it showing incorrect data since I forgot to do that.
Important2 Make sure the "/reviewboard" follows the "reviewboard.wsgi" to become "reviewboard.wsgi/reviewboard" otherwise it will not work and gives a 404 error!
Here's the working version:
<VirtualHost *:80>
ServerAdmin myemail@gmail.com
ServerName www.mysite.com
DocumentRoot "/opt/local/apache2/htdocs/mysite"
ErrorLog "/opt/local/apache2/logs/mysite-error_log"
CustomLog "/opt/local/apache2/logs/mysite-access_log" common
WSGIPassAuthorization On
WSGIScriptAlias /reviewboard /opt/local/apache2/htdocs/mysite/reviewboard/htdocs/reviewboard.wsgi/reviewboard
<Directory /opt/local/apache2/htdocs/mysite/reviewboard>
Allow from all
Options -Indexes +FollowSymLinks
AllowOverride All
</Directory>
# Alias static media requests to filesystem
Alias /reviewboard/media "/opt/local/apache2/htdocs/mysite/reviewboard/htdocs/media"
Alias /reviewboard/static "/opt/local/apache2/htdocs/mysite/reviewboard/htdocs/static"
Alias /reviewboard/errordocs "/opt/local/apache2/htdocs/mysite/reviewboard/htdocs/errordocs"
Alias /reviewboard/favicon.ico "/opt/local/apache2/htdocs/mysite/reviewboard/htdocs/static/rb/images/favicon.png"
</VirtualHost>