By using pbkdf2-sha256 (from your own link) I'm able to generate a hash that is identical to the one you have from Django.
var pbkdf2 = require('pbkdf2-sha256');
var validatePassword = function (key, string) {
var parts = string.split('$');
var iterations = parts[1];
var salt = parts[2];
return pbkdf2(key, new Buffer(salt), iterations, 32).toString('base64') === parts[3];
};
var djangoPass = 'pbkdf2_sha256$10000$NmzpPCQiTe2R$U8ipSsOy3Xz7FwWDHdH/dTei8Xh4Q7NGtdzrCacSfvo=';
console.log(validatePassword('Simple123', djangoPass)); // Logs: true
The above code should be sufficient to validate passwords stored in Django using Node.