Should a new VertexBuffer3D & IndexBuffer3D be created for each Program3D used?

Question

If I have a few Program3D objects (each with it's own Vertex-Shader and Fragment-Shader responsible for it's own rendering task), do I need to instantiate a new VertexBuffer3D and IndexBuffer3D so that they store the data only relevant to the vertex-data format used by their corresponding Program3D?

For example, if I was planning to define Quads in different vertex-data formats, such as:

var vertexData:Vector.<Number>;

//Vertex-Format A:
vertexData = new <Number>[
  //X, Y, U, V
  -.5, -.5, 0, 0,
  .5, -.5, 1, 0,
  .5, .5, 1, 1,
  -.5, .5, 0, 1
];

//Vertex-Format B:
vertexData = new <Number>[
  //X, Y, U, V, Matrix-Constant ID, Color
  -.5, -.5, 0, 0, 3, 0xff0000,
  .5, -.5, 1, 0 , 3, 0x00ff00,
  .5, .5, 1, 1,   3, 0x0000ff,
  -.5, .5, 0, 1,  3, 0xffff00
];

//Vertex-Format C:
vertexData = new <Number>[
  //X, Y, Matrix-Constant ID
  -.5, -.5, 3,
  .5, -.5, 3,
  .5, .5, 3,
  -.5, .5, 3
];

Would I need to create one VertexBuffer3D and IndexBuffer3D to store format A, another one for format B, and yet another one for format C? Or can the various formats be mixed inside the same VertexBuffer3D and then make some clever (or confusing!) use of a single IndexBuffer3D to draw the triangles?